English Synonyms
7-EpicholicAcid;7β-HydroxyisocholicAcid;4-[(5S,7S,8S,10S,13R,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoicacid;Ursocholicacid;(4R)-4-((3R,5S,7S,8R,9S,10S,12S,13R,14S)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoicacid;Ursocholate;UrsodeoxycholicAcidEPImpurityD;ChenodeoxycholicAcidEPImpurityD
Ursodeoxycholic Acid EP Impurity D Properties
| Melting Point | 144 °C |
| Boiling Point | 489.08°C (rough estimate) |
| Density | 1.0263 (rough estimate) |
| Refractive Index | 1.5400 (estimate) |
| Storage Condition | Refrigerator |
| Solubility | Dmso (Mild), Ethanol (Mild, Sonication), Methanol (Mild) |
| Acidity Coefficient (pKa) | 4.76±0.10(Predicted) |
| Form | Solid |
Color
| White to Light Brown |
| Water Solubility | 682.3mg/L(25 ºC) |
Usage and Synthesis of Ursodeoxycholic Acid EP Impurity D
Overview
Ursodeoxycholic Acid Is a Chemical Preparation of Natural Bile Acid Separated from Bear Bile. It Is Present in Bile in Combination with Taurine in the Body. It Is a Hydrophilic Bile Acid and a Cholesterol Stone Dissolving Agent. It Can Reduce the Secretion of Cholesterol by the Liver, Reduce the Saturation of Cholesterol in Bile, Promote the Secretion of Bile Acid, Increase the Solubility of Cholesterol in Bile, Dissolve Cholesterol Stones or Prevent the Formation of Stones. It Can Increase the Amount of Bile Secretion, Relax the Sphincter of the Bile Duct to Produce a Choleretic Effect, And Facilitate the Discharge of Stones. This Product Cannot Dissolve Other Types of Gallstones. It Is Suitable for the Treatment of Cholesterol Stones, Hyperlipidemia, Bile Secretion Disorders, Primary Biliary Cirrhosis, Chronic Hepatitis, Bile Reflux Gastritis and Prevention of Acute Rejection and Reaction of Liver Transplantation. The Stone Dissolving Effect of This Product Is Slightly Weaker Than That of Chenodeoxycholic Acid. Ursodeoxycholic Acid Is an Impurity of Ursodeoxycholic Acid.
Use
Ursocholic Acid Is Suitable for the Treatment of Cholesterol Stones, Hyperlipidemia, Bile Secretion Disorders, Primary Biliary Cirrhosis, Chronic Hepatitis, Bile Reflux Gastritis and Prevention of Acute Rejection and Reaction of Liver Transplantation. The Litholytic Effect of This Product Is Slightly Weaker Than That of Chenodeoxycholic Acid. Ursocholic Acid Is an Impurity of Ursodeoxycholic Acid.
Biological Activity
Ursocholic Acid, A Bile Acid Present in Mammalian Bile, Is Converted to Deoxycholic Acid (Ursodeoxycholic Acid) by Mouse Intestinal Flora. Ursodeoxycholic Acid Is an Inhibitor of 7α-Hydroxysteroid Dehydrogenase and Hepatocyte Nuclear Factor 1α.
Target Spot
Human Endogenous Metabolite
