English Synonyms
Cohedur RK;Developer O;Developer R;Developer RS;developero;developerr;developerrs;Dihydroxybenzol
Resorcinol Properties
| Melting Point | 109-112 °C(lit.) |
| Boiling Point | 281 °C |
| Density | 1.27 |
| Vapor Density | 3.8 (vs air) |
| Vapor Pressure | 1 mm Hg ( 21.1 °C) |
| Refractive Index | 1.5781 |
| Flash Point | 340 °F |
| Storage Conditions | Store below +30°C. |
| Solubility | H2O:1Mat20°C,Clear,Light Yellow |
| Form | Liquid
|
| Color Index | 76505 |
| Acidity Coefficient (pKa) | 9.81(at 25℃) |
| Color | White |
| PH | 4-6 (100g/l, H2O, 20℃) |
| Odor | 1.00% solution in propylene glycol. Nutty flavor |
| Water Solubility | 140 g/100 mL |
| Fragrance | nutty |
| Sensitivity | Light Sensitive |
| Dielectric Constant | 3.2（0.0℃） |
| Stability | Stable. Incompatible with Strong Oxidizing Agents. May Change Color on Exposure to Air or Light. |
Resorcinol Application and Synthesis
Overview
Resorcinol is commonly known as quot;Resorcinol quot;. This product has bactericidal, fungicidal and antipruritic effects. Its bactericidal effect is 1/3 of phenol, and its irritation and corrosiveness are also small. Low concentrations can promote the regeneration of keratin, and high concentrations can peel off keratin.
Pharmacological Action
1% to 2% concentration has antiseptic, bactericidal, antifungal, astringent, antipruritic and keratinizing effects, 5% to 20% concentration has keratin dissolving effect, can make the stratum corneum peel off, 40% concentration has corrosive effect. It can be absorbed through the skin or ulcer surface.
Indications
Used for the treatment of seborrheic dermatitis, acne, superficial fungal skin infections, tinea versicolor, calluses, corns, and common warts.
Use
Resorcinol is mainly used in rubber adhesives, synthetic resins, dyes, preservatives, medicines and analytical reagents. Resorcinol is similar to phenol and cresol. It forms polycondensates with formaldehyde and can be used to make viscose and tire cord adhesives for nylon, prepare wood adhesives, and bond vinyl materials to metals. Resorcinol is an intermediate for many azo dyes and fur dyes, and is also the raw material for the pharmaceutical intermediate p-nitro salicylic acid. Resorcinol has a bactericidal effect and can be used as a preservative, added to cosmetics and skin disease drug pastes and ointments, etc. The derivative of resorcinol, β-methylumbelliferone, is an intermediate for optical bleaching agents, trinitroresorcinol is a detonator, and a considerable amount of resorcinol is used to produce benzophenone ultraviolet absorbers. This product can irritate the skin and mucous membranes, and can be rapidly absorbed through the skin to cause poisoning symptoms. The minimum lethal dose for subcutaneous injection in rats is 450 mg/kg.
Assay and colorimetric determination of zinc, lead, tartaric acid, nitrate and nitrite, colorimetric determination of furfuryl alcohol and sugars, reagents for testing ketose and lignin, reagents for diazo salts, organic synthesis.
Production Method
There are many methods for preparing resorcinol, such as benzene sulfonation alkali fusion method, resorcinol and phenol co-production method, meta-phenylenediamine method, meta-diisopropylbenzene method, meta-aminophenol hydrolysis method, etc. The benzene sulfonation alkali fusion method uses benzene as raw material, sulfonates to obtain isophenyl disulfonic acid, and then neutralizes and alkali-melts and acidifies to obtain it. Benzene, 65% fuming sulfuric acid and sodium sulfate are added to the reactor respectively, and the reaction temperature is controlled at 75°C to obtain a sulfonate. Then add anhydrous sodium sulfate to the sulfonate, stir and heat to 175°C to dissolve it, add sulfur trioxide at this temperature, and react for 1.5 hours to obtain a disulfonate (benzenedisulfonic acid content 75%). The disulfonated product is neutralized with a dilute alkali solution and excess sulfate is removed. The resulting sodium benzene disulfonic acid salt is gradually added to molten sodium hydroxide at 290°C, and the temperature is raised to 325°C within 15 minutes. The alkali melt is then dissolved in water, acidified with sulfuric acid, extracted with ether, and the solvent is evaporated to obtain the finished product of resorcinol.
