Propyl Gallate CAS 121-79-9
propyl gallate CAS 121-79-9propyl gallate CAS 121-79-9

Propyl Gallate CAS 121-79-9

propyl gallate CAS 121-79-9, propyl gallate, CAS 121-79-9

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In the vast world of chemistry, propyl gallate, as a unique substance, demonstrates its distinctive physical and chemical properties. Propyl gallate appears as a white to light brown crystalline powder or slightly milky white needle-like crystals. Its unique texture on the surface seems to be a mysterious mark bestowed upon it by nature.

121-79-9

C10H12O5

212.2

204-498-2

Propyl Gallate CAS 121-79-9 Information


Chemical Name

Propyl Gallate

Other Name

PG; Gallic acid propyl ester; Gallic acid

CAS

121-79-9

EINECS

204-498-2

Type

Food additives; Feed additives; Pharmaceutical raw materials; Flavors and fragrances; Plant extracts; Organic raw materials

Molecular Formula

C10H12O5

Molecular Weight

212.2




Propyl Gallate CAS 121-79-9 Properties


Melting point 

146-149 °C(lit.)

Boiling point 

312.03°C (rough estimate)

density 

1.210

vapor pressure 

0Pa at 20℃

refractive index 

1.5140 (estimate)

Fp 

187℃

storage temp. 

Store below +30°C.

solubility 

ethanol: 50 mg/mL

form 

powder



What is Propyl Gallate?


In the vast world of chemistry, propyl gallate, as a unique substance, demonstrates its distinctive physical and chemical properties. Propyl gallate appears as a white to light brown crystalline powder or slightly milky white needle-like crystals. Its unique texture on the surface seems to be a mysterious mark bestowed upon it by nature. When we get close to smell it, we will find that it has no obvious stench. However, when we place it on the tip of our tongue, we can slightly sense a bitter taste. Interestingly, when it dissolves in water to form a water solution, this bitter taste seems to vanish without a trace, making it hard to notice.

From the perspective of solubility, propyl gallate (abbreviated as PG) has extremely poor solubility in water and is almost insoluble in water, a common solvent. However, it can smoothly dissolve in organic solvents such as ethanol, as if it has some special affinity with these organic solvents. Meanwhile, its solubility in oils such as cottonseed oil, peanut oil and lard is also relatively limited, only showing a slightly soluble state. It is worth mentioning that when it is prepared into a 0.25% aqueous solution and detected by a precise pH measurement instrument, we will find that its pH value is approximately stable at around 5.5. This specific pH value seems to be an accurate measurement of its inherent chemical properties.

Propyl gallate also has its own unique performance in terms of chemical stability. Under normal conditions, it is relatively stable. However, once it encounters metal ions such as copper and iron, it is like a calm lake surface being thrown with stones. It will quickly react with these metal ions, and its original color will change accordingly, gradually turning purple or dark green. This color change seems like a wonderful "dialogue" between it and the metal ions. It visually demonstrates the changes in its chemical properties. In addition, it also has good hygroscopicity, just like a small "sponge", capable of absorbing moisture from the surrounding environment. Meanwhile, it is highly sensitive to light. The exposure to light will gradually disintegrate its internal chemical structure, leading to decomposition reactions. Moreover, its high-temperature resistance is poor. Under high-temperature conditions, the stability of its chemical properties is difficult to guarantee.

Propyl gallate, apart from being called PG, also has several other names such as propyl gallate and Tongmai lipid. These different names seem to be its multiple "business cards" in the field of chemistry. Its white to light brown crystalline powder form is not merely a simple physical appearance, but a notable feature of it as one of the important derivatives of the plant polyphenol gallic acid. Among numerous enterprises, Jiurui Company regards it as its flagship product, which is sufficient to demonstrate its significance and unique value in the relevant field.

A thorough exploration of its chemical structure reveals that the polyphenol structure contained in propyl gallate endows it with a series of excellent properties. Among them, the most prominent feature is its outstanding antioxidant performance, which is like a loyal "guardian", effectively resisting the damage of oxidation reactions to substances and extending the service life of other substances. Meanwhile, it also has a strong chelating ability with various metal ions. This ability enables it to closely combine with metal ions when facing complex chemical environments, forming stable compounds and thus exerting unique chemical effects.

It is precisely because of these excellent properties of propyl gallate that it has been widely applied in many fields. In the food and feed industry, it plays a crucial role as an antioxidant, preventing components such as oils in food and feed from deteriorating due to oxidation, and maintaining their fresh quality and taste. In the field of fruit and vegetable preservation, it is like a considerate "preservation guardian". Through its own antioxidant and chelating effects, it delays the aging and spoilage process of fruits and vegetables, allowing them to maintain their freshness and nutritional value for a longer time. In the field of medicine, it is used in the research and development and production of monomer antithrombotic drugs, providing strong support for the treatment of thrombosis and related diseases. Even in the cosmetics industry, it has, with its own characteristics, added a layer of guarantee to the stability and efficacy of cosmetics, becoming a "secret weapon" in many cosmetic formulas.

However, everything has two sides, and propyl gallate is no exception. Because it is itself an antioxidant, it is prone to oxidation due to the influence of external factors during storage. As time passes quietly and the storage period extends continuously, the content of propyl gallate will gradually decrease, which is as if its "energy" is being slowly exhausted. Therefore, in order to ensure an accurate grasp of its content and reduce errors caused by content changes, we need to test and analyze the samples in a timely manner, just like conducting regular "health check-ups" for them.

In practical applications, the dosage of propyl gallate is strictly limited. When its usage reaches 0.01%, the coloring phenomenon will begin to occur. This characteristic limits the range of its sole use to a certain extent. Therefore, in actual operation, it is generally not used alone but in combination with other substances such as BHA and BHT to achieve better results and avoid coloring issues. Moreover, through scientific research and application practice, it has been stipulated that the total amount of BHA and BHT used in combination shall not exceed 0.1g/kg, and the dosage of propyl gallate shall not exceed 0.05g/kg. These strict regulations are like a series of "safety lines of defense", ensuring the safety and effectiveness of propyl gallate in various fields.




Biological Effects



In 1993, in a rigorous and in-depth study conducted by researchers on obese rodents, after a series of meticulous experimental designs, strict experimental operations and comprehensive data analysis, it was ultimately found that propyl gallate played an extremely minor role in causing cancer. This research result provides an important reference basis for subsequent related studies on propyl gallate and also enables people to have a new understanding of its potential safety.

As time went by, in 2009, another professional research achieved significant results. This study, through advanced technical means and scientific experimental methods, deeply explored the characteristics of propyl gallate and ultimately clearly discovered that propyl gallate is an estrogen antagonist. This discovery further enriches people's understanding of the biological characteristics of propyl gallate and opens up new directions for its application and research in related fields.

Propyl gallate, as a substance with unique chemical properties, has demonstrated a variety of remarkable biological activities. Specifically, in terms of enzyme inhibition, it can exert inhibitory effects on specific enzymes, influencing the metabolic processes within the organism by regulating the activity of enzymes, and thereby exerting its unique physiological effects.

In terms of antibacterial activity, propyl gallate demonstrated a significant ability to inhibit bacterial growth and reproduction. It can interfere with the normal physiological functions of bacteria and destroy their living environment, thereby effectively resisting bacterial invasion and providing possible research ideas for the prevention and treatment of certain bacterial infectious diseases.

In addition, propyl gallate also has the effect of inhibiting the formation of nitrosamines. Nitrosamines, as a known strong carcinogen, pose a serious threat to human health. Propyl gallate can prevent the formation of nitrosamines through specific chemical mechanisms, thereby reducing the risk of cancer to a certain extent and providing a new approach for cancer prevention.

In terms of anti-cancer effects, propyl gallate has demonstrated Anticancerous effects, that is, it has a certain inhibitory effect on the growth and proliferation of cancer cells. It can interfere with the metabolic process of cancer cells, induce apoptosis of cancer cells, or inhibit the metastasis and invasion of cancer cells, bringing new hope to the treatment of cancer.

Meanwhile, propyl gallate also has Antitumorigenicity, that is, the property of anti-tumor generation. It can regulate the immune system of the body through multiple pathways, enhance the body's immune surveillance and immune clearance capabilities against tumors, thereby inhibiting the occurrence and development of tumors.

Not only that, propyl gallate also has analgesic effects. When the human body is stimulated by pain, propyl gallate can act on the nervous system, regulating the release and transmission of neurotransmitters, thereby reducing the perception of pain and providing a potential therapeutic option for alleviating pain symptoms.

In terms of the biosynthetic process, propyl gallate can inhibit the synthetic reactions in organisms. It can interfere with the synthetic pathways of biomolecules, affect the synthesis of biological macromolecules such as proteins and nucleic acids, and thereby exert regulatory effects on the growth, differentiation and metabolism of cells.

In addition, propyl gallate also has the function of ionization/ultraviolet (UV) protection. It can absorb and shield the energy of ionizing radiation and ultraviolet rays, reduce the damage caused by these radiations to organisms, protect the DNA of cells and other biomolecules from the destruction of radiation, and is of great significance for maintaining the health and stability of organisms.

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