English Synonyms
6,17-alpha Epoxypregnenolone;Phloroglucinol >=99.0% (HPLC);Floroglucin;Floroglucinol;Phloroglucine;Spasfon-Lyoc;s-Trihydroxybenzene;sym-Trihydroxybenzene
Phloroglucinol Properties
| Melting Point | 215-220 °C |
| Boiling Point | 194.21°C (rough estimate) |
| Density | 0.801 g/mL at 20 °C |
| Vapor Pressure | 0.001Pa at 25℃ |
| Refractive Index | n20/D 1.365 |
| Flash Point | 14 °C |
| Storage Conditions | Store Below +30°C. |
| Solubility | Soluble in Ether, Ethanol and Pyridine. |
| Form | Crystalline Powder |
| Acidity Coefficient (pKa) | pK1:8.45(0);pK2:8.88(-1) (25°C) |
Phloroglucinol Uses and Synthesis Methods
Introduction
Phloroglucinol (1,3,5-trihydroxybenzene) is an important fine chemical product, mainly used as an intermediate in drug synthesis, such as flavonoids. As drugs for the treatment of cardiovascular and cerebrovascular diseases, flavonoids have attracted more and more attention from pharmacologists.
Pharmacological Uses
The ATC code of phloroglucinol is A03AX12, which treats functional intestinal diseases and can treat gastrointestinal diseases such as gallstones. Acylated phloroglucinol can also be used as an inhibitor of fatty acid synthase. The common form of medication is injection. In addition to phloroglucinol as the active ingredient, the injection also contains trimethylphloroglucinol, sodium chloride, sodium bisulfite, citric acid, disodium hydrogen phosphate dodecahydrate, etc. Excipients.
Security
There are 39 clinical trials to observe the safety and tolerability of phloroglucinol. Among the 2,598 patients treated with phloroglucinol, only a few patients reported occasional dizziness, nausea and other adverse reactions, but these symptoms are common in It will disappear on its own after stopping the drug or reducing the dose, and there are very few allergic reactions, such as rashes! It has no teratogenic or mutagenic properties, such as measles, and clinical application results over the years have shown that it has no adverse effects on mothers and fetuses. Effect, proving the safety of its application in the field of gynecology. All patients treated with intramuscular and intravenous injections have good compliance with phloroglucinol. The safety of long-term medication and high-dose medication is also very good - due to phloroglucinol Phenol does not have atropine-like adverse reactions and is safe for use in patients with glaucoma and prostatic hypertrophy.
Use
Determination of antimony, arsenic, cerium, chromate, chromium, gold, iron, mercury, nitrite, osmium, palladium, tin, vanadium, vanillin and lignin, etc., determination of furfural, pentose, polypentosose, methanol , chloral hydrate, turpentine, hydrochloric acid in lignified cell tissue and gastric juice, decalcification of bone specimens.
Used as biological reagents = dyes, and used to test vanillin, lignin, determine furfural, polypentose, etc.
