Phloroglucide cas 491-45-2-Deshangchemical

Phloroglucide cas 491-45-2

chem

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English SynonymsPHLOROGLUCIDE;PHBF;2,3',4,5',6-Pentahydroxybiphenyl;1,1'-Biphenyl-2,3',4,5',6-pentol;Biphenyl-2,3',4,5',6-pentol;Phloroglucidol;Phloroglucide hydrate,95%;2,4,6,3',5'-BiphenylpentolPhloroglucide propertiesMelting Point300 °CBoiling Point529.5±40.0

CAS

491-45-2

Molecular Formula

C12H10O5

Molecular weight

234.2

English Synonyms

PHLOROGLUCIDE;PHBF;2,3',4,5',6-Pentahydroxybiphenyl;1,1'-Biphenyl-2,3',4,5',6-pentol;Biphenyl-2,3',4,5',6-pentol;Phloroglucidol;Phloroglucide hydrate,95%;2,4,6,3',5'-Biphenylpentol

Phloroglucide properties

Melting Point	300 °C
Boiling Point	529.5±40.0 °C(Predicted)
Density	1.594±0.06 g/cm3(Predicted)
Storage Conditions	Dark Room
Solubility	Soluble in DMSO (a little), Methanol (a little)
Form	Powder
Acidity Coefficient (pKa)	8.63±0.40(Predicted)
Color	Yellow to Brown
Sensitivity	Light Sensitive
Stability	stability

Phloroglucide Uses and Synthesis Methods

Application

Phloroglucide is a very important pharmaceutical intermediate with an extremely wide range of applications.

Preparation

Step 1: Add mesotriphenol (47.6 mol, 6 kg) to 24 liters of trifluoroacetic acid, stir under reflux for 20 hours. Step 2: Evaporate 15 liters of trifluoroacetic acid under reduced pressure to obtain residual solid. Step 3: Add 10 liters of methylene chloride to the residual solid, stir to form a uniform slurry, filter, wash the solid with methylene chloride, and dry 5 kg of pink crude product. Figure 1 shows the HPLC chart of the crude product. Step 4: Take 2 kilograms of crude product, add 20 liters of water, adjust the pH to 8 to 9 with sodium carbonate, stir under reflux for 18 hours, cool to room temperature, filter out the solid, and dry to obtain 1.5 kilograms of light earthy yellow solid product.

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