English Synonyms
PHLOROGLUCIDE;PHBF;2,3',4,5',6-Pentahydroxybiphenyl;1,1'-Biphenyl-2,3',4,5',6-pentol;Biphenyl-2,3',4,5',6-pentol;Phloroglucidol;Phloroglucide hydrate,95%;2,4,6,3',5'-Biphenylpentol
Phloroglucide properties
| Melting Point | 300 °C
|
| Boiling Point | 529.5±40.0 °C(Predicted)
|
| Density | 1.594±0.06 g/cm3(Predicted) |
| Storage Conditions | Dark Room |
| Solubility | Soluble in DMSO (a little), Methanol (a little) |
| Form | Powder |
| Acidity Coefficient (pKa) | 8.63±0.40(Predicted) |
| Color | Yellow to Brown |
| Sensitivity | Light Sensitive |
| Stability | stability |
Phloroglucide Uses and Synthesis Methods
Application
Phloroglucide is a very important pharmaceutical intermediate with an extremely wide range of applications.
Preparation
Step 1: Add mesotriphenol (47.6 mol, 6 kg) to 24 liters of trifluoroacetic acid, stir under reflux for 20 hours. Step 2: Evaporate 15 liters of trifluoroacetic acid under reduced pressure to obtain residual solid. Step 3: Add 10 liters of methylene chloride to the residual solid, stir to form a uniform slurry, filter, wash the solid with methylene chloride, and dry 5 kg of pink crude product. Figure 1 shows the HPLC chart of the crude product. Step 4: Take 2 kilograms of crude product, add 20 liters of water, adjust the pH to 8 to 9 with sodium carbonate, stir under reflux for 18 hours, cool to room temperature, filter out the solid, and dry to obtain 1.5 kilograms of light earthy yellow solid product.
