Nuciferine CAS 475-83-2 Information
| CAS |
475-83-2 |
| Molecular formula |
C₁₉H₂₁NO₂ |
| Molecular weight |
295.38 |
| EIENCS |
618-170-5 |
| Form |
powder |
| Melting point |
165.5°C |
| boling point |
437.06°C (rough estimate) |
| Density |
1.1156 (rough estimate) |
| Solubility |
|
| PKA |
/ |
| Color |
/ |
| Storage temp |
|
What is Nuciferine CAS 475-83-2?
Nuciferine (CAS 475-83-2) is a multifunctional alkaloid from lotus leaves with broad therapeutic potential in metabolic disorders (diabetes, hyperlipidemia), cancer cachexia, inflammation, and neuroprotection. Its mechanisms involve dual modulation of serotonin/dopamine receptors, ferroptosis inhibition, and GLUT4/AMPK activation. While commercially available for research (purity up to 99.71%), challenges like solubility and comprehensive toxicity profiles require further optimization
. For therapeutic use, prioritize pharmaceutical-grade material (≥98%) and monitor CYP2D6 interactions clinically.
Nuciferine CAS 475-83-2 Use
Key Targets:
Serotonin Receptors:
Antagonist of 5-HT₂c (IC₅₀=131 nM), 5-HT₂A (IC₅₀=478 nM), 5-HT₂B (IC₅₀=1 μM) .
Inverse agonist of 5-HT₇ (IC₅₀=150 nM) .
Dopamine Receptors: Partial agonist of D₂ (EC₅₀=64 nM) .
Pharmacological Effects:
Anticancer & Anti-Cachexia:
Binds directly to HSP90AA1, activating AKT-mTOR and suppressing NF-κB pathways to reduce muscle atrophy in cancer cachexia .
In mice, 10 mg/kg nuciferine improved grip strength by 29.7% and reduced degradation of muscle proteins (Atrogin1/MuRF1) .
Antidiabetic:
Enhances GLUT4 translocation via AMPK and PKC pathways, boosting glucose uptake in L6 cells by 2.8-fold .
Reverses liver steatosis and pancreatic islet hypertrophy in diabetic mice .
Anti-Inflammatory:
Inhibits NF-κB activation by degrading IκB-α in LPS-stimulated RAW264.7 cells, dependent on PPAR pathways .
Otoprotection:
At 90 μM, protects cochlear hair cells from cisplatin-induced ferroptosis by inhibiting NCOA4-mediated ferritinophagy .
Antipsychotic Potential:
Blocks 5-HT₂A agonist effects, rescues PCP-induced behavioral disruptions in rodents without catalepsy .
Nuciferine CAS 475-83-2 safety
Acute Toxicity:
Rat oral LD₅₀: 280 mg/kg .
Low skin irritation (rabbit dermal LD₅₀ >5000 mg/kg) .
Drug Interactions:
Inhibits CYP2D6, caution with anti-arrhythmia drugs (e.g., amiodarone, metoprolol) .
Side Effects:
High doses may cause minor cytotoxicity or reversible peripheral neuropathy .
Deshangchemical Info
- ● Comgpany name : Shandong Deshang Chemicals Co., Ltd.
- ● Main products : Treatments, sedimentation agents, flame retardants, catalysts, matte pigments, talcum powder, PVC additives, antifreeze agents, cellulose, cleaning agents, coconut oil, hydroxyethyl, cosmetics, matte agents, betaine, disinfectants, photosensitizers, humidifying agents, blue pigments, curing agents, potassium formate, sodium formate, cyclohexanol, preservatives, grinding aids.
- ● Date of establishment : 2022-03-11
- ● Total Employees : 200+
- ● Registered capital: 10000000 RMB
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