N-(Trimethylsilyl)imidazole CAS 18156-74-6 Information
| CAS |
18156-74-6 |
| Molecular formula |
C6H12N2Si |
| Molecular weight |
140.26 |
| EIENCS |
242-040-3 |
| Form |
Liquid |
| Melting point |
-42 °C |
| boling point |
93-94 °C14 mm Hg(lit.) |
| Density |
0.957 g/mL at 20 °C |
| Solubility |
decomposes |
| PKA |
7.96±0.10(Predicted) |
| Color |
Clear colorless to yellow |
| Storage temp |
Store below +30°C. |
What is N-(Trimethylsilyl)imidazole CAS 18156-74-6?
N - (trimethylsilyl) imidazole (CAS 18156-74-6), also known as trimethylsilyl imidazole or trimethylsilyl imidazole, the following is its detailed information:
Basic information
Chinese name: N - (trimethylsilyl) imidazole
English name: N - (Trimethylsilyl)imidazole
Alternative names: Trimethylsilyllimidazole, trimethylsilyllimidazole, 1-Trimethylsilyllimidazole, etc
Molecular formula: C₆H₁₂N₂Si
Molecular weight: 140.26
EINECS login number: 242-040-3
Physical properties
Appearance: Some sources indicate it as a colorless and transparent liquid, while others describe its appearance as uncertain.
Melting point: Different materials record the melting point differently, with some indicating -42 °C and others having uncertain expressions. This may be due to factors such as measurement methods and sample purity, resulting in variations.
Boiling point: 93-94℃ (14mmHg).
Density: 0.92g/cm³
0.956g/mL (20 °C)
0.957g/mL (20/4℃). The differences among different data may be related to the measurement conditions.
Refractive index: 1.475-1.478 (n20/D)
1.475 (lit.).
Flash point: 42 °F (approximately 5.56 ° C).
N-(Trimethylsilyl)imidazole CAS 18156-74-6 Use
In the pharmaceutical field, it is an intermediate for antibiotics and can be used to synthesize various acylimidazoles, pyranoamide, etc. It is also an important intermediate for the synthesis of pyranoamide. Under amine functionalization conditions, it can be used as a silanization reagent to protect hydroxyl groups for the preparation of multiple derivatives of compounds containing both hydroxyl and amino groups. Silanized sugar can be used in the presence of a small amount of water. It is an ideal choice when sugar needs to be analyzed as a syrup agent. Most steroid hydroxyl groups can be derived without obstruction or with severe obstruction.
In the field of organic synthesis: It is an extremely powerful silanizing agent. As a powerful silanizing reagent, it is particularly targeted at alcohols. It is a commonly used silanizing reagent in organic chemistry and can be used for the protection of organic synthetic groups.
