Isonicotinic acid CAS 55-22-1 Information
| CAS |
55-22-1 |
| Molecular formula |
C6H5NO2 |
| Molecular weight |
123.11 |
| EIENCS |
200-228-2 |
| Form |
powder |
| Melting point |
≥300 °C (lit.) |
| boling point |
260 °C (15 mmHg) |
| Density |
1,47g/cm |
| Solubility |
5.2 g/L (20 ºC) |
| PKA |
4.96(at 25℃) |
| Color |
yellow to tan |
| Storage temp |
no restrictions |
What is Isonicotinic acid CAS 55-22-1?
1.Isnicotinic acid is a widely used intermediate. Mainly used as isoniazid (ramiphen), terfenadine, isoniacic acid and other first-line anti-tuberculosis drugs raw materials, can also be used as preservatives, electroplating additives, photosensitizers. Resin stabilizer, PVC heat stabilizer, non-ferrous metal flotation agent, etc.
2.Isoniazid can be obtained by condensation and melting dehydration of isoniazid and hydrazine hydrate. Isoniazid has good antibacterial effect on mycobacterium tuberculosis, good efficacy, small dosage, relatively low toxicity. It is used to treat all forms of tuberculosis. It can also be used for advanced tuberculous meningitis and other extrapulmonary tuberculosis, during the period of dissolution and spread, and during the period of improved absorption. These preparations include tablets and injections.
3.It is used as a pharmaceutical intermediate, mainly for the production of anti-tuberculosis drug isoniazid, and also for the synthesis of derivatives such as amides, hydrazides, and esters.
4.Isonicotinic acid, also known as pyridine 4-carboxylate, is an intermediate of the plant growth regulator Trexamine, as well as an intermediate of isoniazid, a medicinal anti-tuberculosis drug.
Isonicotinic acid CAS 55-22-1 Use
4-pyridinic acid, also known as isonicotinic acid, is an organic compound with a specific chemical structure and properties. Its molecular formula is C6H5NO2, and its structural formula demonstrates its unique molecular arrangement. This white needle-like crystalline powder is odorless and has a relatively high melting point and sublimation point.
In terms of solubility, isonicotinic acid exhibits certain amphoteric characteristics, being soluble in both acids and bases. When reacting with acid, it can form pyridine salts; And when reacting with alkali, carboxylate salts can be formed. It is worth noting that isonicotinic acid mainly exists in the form of an inner salt in aqueous solution, that is, it stably exists in the form of a zwitterion.
As a widely used intermediate, isonicotinic acid has important applications in the field of medicine. It can serve as a key raw material for the synthesis of other drugs or active ingredients, providing significant support for the pharmaceutical industry.
Regarding the methods for synthesizing isonicotinic acid, there are indeed multiple approaches. Among them, oxidation method, hydrolysis method and biocatalysis method are several relatively common methods. Oxidation methods include traditional chemical oxidation methods such as potassium permanganate oxidation and nitric acid oxidation, as well as electrochemical oxidation methods. These methods each have their own characteristics, and appropriate process conditions can be selected according to actual needs to prepare isonicotinic acid.
Overall, isonicotinic acid, as an important organic compound, plays a significant role in fields such as medicine. Through reasonable synthesis methods and strict quality control, it can be ensured that it is safely and effectively applied in related fields. At the same time, we should also pay attention to its potential risks and challenges and take corresponding measures to ensure its rational use and management.
