Ibuprofen EP Impurity E cas 38861-78-8-Deshangchemical

Ibuprofen EP Impurity E cas 38861-78-8

chem

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English SynonymsImp. E:1-(4-isobutylphenyl)ethanone;TIMTEC-BB SBB007668;P-ISO-BUTYLACETOPHENONE;IBUPROFEN IMPURITY E;IBUPROFEN IMP E;ISOBUTYL ACETOPHENONE;4'-Isobutylacetophenone, 97+%;4'-ISOBUTYLACETOPHENONEIbuprofen EP Impurity E PropertiesBoiling Point134-135°C 16mmDensity0,952 g/cm3Vapo

CAS

38861-78-8

Molecular Formula

C12H16O

Molecular weight

176.26

English Synonyms

Imp. E:1-(4-isobutylphenyl)ethanone;TIMTEC-BB SBB007668;P-ISO-BUTYLACETOPHENONE;IBUPROFEN IMPURITY E;IBUPROFEN IMP E;ISOBUTYL ACETOPHENONE;4'-Isobutylacetophenone, 97+%;4'-ISOBUTYLACETOPHENONE

Ibuprofen EP Impurity E Properties

Boiling Point	134-135°C 16mm
Density	0,952 g/cm3
Vapor Pressure	0.75Pa at 20℃
Refractive Index	1.5180
Flash Point	54°C
Storage Conditions	Keep in Dark Place,Inert Atmosphere,Room Temperature
Solubility	Soluble in dichloromethane; ether; ethyl acetate; tetrahydrofuran
Color	Colorless to Yellow
Water Solubility	Miscible with chloroform and methanol. Slightly miscible with water.

Use and Synthesis of Ibuprofen EP Impurity E

Use

In medicine, it is used to synthesize antipyretic and analgesic drugs such as ibuprofen.

Production Method

Toluene is reacted with propylene in the presence of metallic potassium, sodium carbonate and graphite, the methyl group is alkylated to form isobutylbenzene, which is then acetylated with acetyl chloride in the presence of anhydrous aluminum chloride to obtain this product.

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