Dyestuff Intermediate

Dihydrocoumarin, also known as 1, 2-benzo-dihydropyranone, Tongkamel and meliltine, is a natural product found in plants such as luteum. This compound has a coumarin-like aroma at room temperature, but emits a nitrobenzene-like smell at high temperatures. It has a pungent taste and appears as a colorless or pale yellow viscous liquid, sometimes also in the form of leaf-like crystals. Its relative molecular weight is 148.17, the relative density is 1.169 (at 18°C), the melting point is 25 °C, the boiling point is 272 °C, and it is 145 °C under a pressure of 2.400×10 ³ Pa. The refractive index is 1.5563 and the flash point is 130°C. It is slightly soluble in water, soluble in ethanol and ether, and highly soluble in chloroform. When steam comes into contact with the skin, eyes and respiratory tract, it can cause irritation. According to the test results of oral LD50 in rats, its value is 1460mg/kg.

Hydrocinnamate lactone appears as a white or grayish-white solid at normal temperature and pressure. This type of compound belongs to the lactone class and is widely used in organic synthesis, biochemistry and fine chemical fields, serving as a derivatization and modification tool for drug molecules, pesticide molecules and bioactive molecules. In addition, hydrogenated cinnamate lactone can also be used as a food flavor additive.

Dihydrocoumarin (DHC) is renowned for its unique sweetness, creaminess and herbal aroma, with a hint of caramel. It can be used as a flavoring agent for a variety of products such as food, tobacco, soap and perfume. Its flavor characteristics make it an ideal choice for caramel, nuts, dairy products, vanilla, tropical fruits and alcoholic beverages. As a eukaryotic metabolite, dihydrocoumarin was first discovered in the Lingling bean growing in northern South America and was isolated from these plants and other sweet clover varieties in the 1820s. In addition to the above applications, it can also be used as an organic solvent and a pharmaceutical intermediate, and studies have shown that it can affect the epigenetic processes of human cells in vitro.

Hydrocoumarin CAS 119-84-6 Uses

In the field of spices, hydrocoumarin has extensive and important applications. It is often used in tobacco flavoring, which can add a unique aroma and flavor to tobacco, making it emit a more alluring and layered fragrance during the smoking process, and meeting consumers' diverse demands for tobacco flavors. Meanwhile, in terms of food flavorings, hydrocoumarin also plays an indispensable role. It can be integrated into various types of food, such as baked goods, candies, and beverages, endowing these foods with a fresh and elegant aroma, enhancing the taste and quality of the food, and allowing consumers to enjoy delicious food while experiencing a wonderful olfactory experience. In addition, in the blending of various other types of fragrances, hydrocoumarin also plays a crucial role. It can be combined with other spices to create a rich variety of distinctive fragrance products, meeting the specific fragrance requirements of different industries.

In the fields of chemical research and drug development, hydrogenated coumarin has unique value. It can be used as a special reagent to participate in the preparation process of mitomycin analogues. This mitomycin analogue has significant research significance because it can be used as a Sir2 inhibitor. In the related research of cell biology and drug development, Sir2 inhibitors have attracted much attention. The mitomycin analogues synthesized with the participation of hydrogenated coumarin provide powerful tools and research objects for scientists to further explore related biological processes and develop potential drugs, which is conducive to promoting the scientific research progress and drug innovation in related fields.

In the field of analytical chemistry, dihydrocoumarin has special uses. It can be used as a standard substance and applied in chromatography and capillary electrophoresis for the determination of analytes in various substances. For instance, in the detection of melon extract, dihydrocoumarin, as a standard substance, can assist researchers in accurately analyzing and identifying various components in melon extract, ensuring its quality and safety, and providing a scientific basis for the development and quality control of melon-related products. In terms of the analysis of drug preparations, it is equally indispensable. By comparing and analyzing with the components in the drug preparations, the quality and purity of the drugs can be effectively monitored, ensuring the safety of patients' medication. In addition, for various plant extracts, dihydrocoumarin, as a standard substance, can help researchers gain a deeper understanding of the composition of plant extracts in chromatography and capillary electrophoresis determination, providing an important reference for the rational development and utilization of plant resources.