English Synonyms
FLUOROBENZENE;Fluorobenzene,min.97%;(1Mg/MLinMethanol)[InternalstandardforWaterAnalysis];FluorobenzeneFluorobenzene,99%500GR;FLUOROBENZENEFORSYNTHESIS250ML;FLUOROBENZENEFORSYNTHESIS5ML;Fluorinebenzene
Fluorobenzene Properties
| Melting Point | -42 °C |
| Boiling Point | 85 °C(lit.) |
| Density | 1.024 g/mL at 25 °C(lit.) |
| Vapor Density | 3.31 (vs air) |
| Vapor Pressure | 81hPa at 20℃ |
| Refractive Index | n20/D 1.465(lit.) |
| Flash Point | 9 °F |
| Storage Condition | 2-8°C |
| Solubility | 1.54g/l |
| Form | Liquid |
| Color | Transparent and Colorless |
| Relative Polarity | 3.3 |
| Explosive Limit | 1.3-8.9%(V) |
| Water Solubility | INSOLUBLE |
| Dielectric Constant | 4.7（60℃） |
Fluorobenzene Usage and Synthesis
Use
This Product Is Mainly Used as the Main Raw Material for the Preparation of Antipsychotic Specific Drugs Such as Fluphenazine, Daropentinol, Trifluoperidol, Trifluoperidol, Penfluridol, And Quinolone Drugs-Ciprofloxacin. It Is Also Used for the Identification of Pesticides, Insecticides, And Ovicides, As Well as Plastics and Resin Polymers. The Condensation of Fluorobenzene with γ-Chlorobutyryl Chloride Can Produce γ-Chloro-P-Fluorobutyrophenone, Which Is Used to Synthesize Haloperidol, Which Is the Most Commonly Used Drug Among Butyrophenone Antipsychotic Drugs.
It Is Mainly Used to Prepare Antipsychotic Drugs Such as Haloperidol, And Is Also Used as an Insecticide and for the Identification of Plastics and Resin Polymers.
Production Method
1. Obtained by Schiemann reaction of aniline. After aniline is salted with 31% hydrochloric acid, it is cooled to -8°C and diazotized with sodium nitrite solution. The diazo solution is cooled to -10°C, and fluoroboric acid solution is added to generate fluoroboric acid diazonium salt with low solubility, which is filtered. The fluoroboric acid diazonium benzene is dried and pyrolyzed. At the same time, the generated fluorobenzene is distilled out, and the distillate is washed with sodium hydroxide solution, then washed with water, dried and distilled to obtain the finished product with a yield of about 53%. This method consumes a large amount of boric acid, produces a lot of waste gas, and has a high cost. 2. Use dry sodium nitrite to react with aniline in anhydrous hydrogen fluoride, and then keep the diazo compound solution below 40°C, with a yield of 80%. The advantages of this method are low cost and less waste gas. 3. Trifluoroacetic anhydride method: trifluoroacetic anhydride and cyclohexane are used.3. Trifluoroacetic Anhydride Method: Trifluoroacetic Anhydride and Cyclohexane Are Used as Raw Materials, And After Addition Reaction, They Are Reacted with Hydrogen Fluoride to Produce 1,1-Difluorocyclohexane and Trifluoroacetic Acid; 1,1-Difluorocyclohexane Is Then Dehydrogenated and Dehydrofluorinated to Obtain Fluorobenzene.
