English Synonyms
DEOXYCHOLIC ACID;DESOXYCHOLIC ACID;CHOLEIC ACID;CHOLAIC ACID;7-DEOXYCHOLIC ACID;5BETA-CHOLAN-3ALPHA, 12BETA-DIOL;5BETA-CHOLAN-24-OIC ACID-3ALPHA,12ALPHA-DIOL;5-BETA-CHOLANIC ACID-3-ALPHA, 12-ALPHA-DIOL
Deoxycholic Acid properties
| Melting Point | 171-174 °C(lit.) |
| Specific Rotation | 55 º (c=1, EtOH) |
| Boiling Point | 437.26°C (rough estimate) |
| Density | 0.9985 (rough estimate) |
| Vapor Pressure | 0.004Pa at 20℃ |
| Refractive Index | 1.4460 (estimate) |
| Flash Point | 9℃ |
| Solubility | 0.24g/l(15°C) |
| Form | Solid |
| Color | White to Off-White |
Uses and Synthesis of Deoxycholic Acid
Introduction
Deoxycholic Acid Was Developed by Kythera Biopharmaceuticals and Approved by the U.S. Food and Drug Administration (Fda) in April 2015 as the World's First Topical Lipolysis Drug. Deoxycholic Acid Is a Free Bile Acid Present in Bile. It Has Strong Surface Activity and Can Destroy and Dissolve Cell Membranes, Thereby Reducing the Dissolution of Local Subcutaneous Fat in a Small Area. In Clinical Trials, Deoxycholic Acid Can Effectively Eliminate Submental Fat and Improve Overall Appearance Compared to Placebo.
Application
Deoxycholic Acid Is Used to Treat and Improve Moderate to Severe Bulge or Fullness of Submental Fat (Double Chin) in Adults.
Content Analysis
The Method Is the Same as "cholic Acid (10005)", Except That the Sample Size Is Changed to About 500 Mg. When Calculating, Each Ml of 0.1 Mol/L Sodium Hydroxide Is Equivalent to 39.26 Mg of Deoxycholic Acid (C24h40o4).
Chemical Properties
Slightly Soluble in Water, Soluble in Ethanol, Ether, Trichloromethane, Acetone, Glacial Acetic Acid, Soluble in Alkali Hydroxide and Carbonate Solutions. It Is Derived from a Cholanic Acid Extracted from Pig Bile.
Use
Bacteriological and Enzymatic Studies; Used for Solubilization of β-Adrenergic Receptors.
