English Synonyms
DL-DapoxteineHCL;N,N-DiMethyl-1-phenyl-3-(1-naphthalenyloxy)propanaMinehydrochloride;(S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-aminehydrochloride;Dapoxetine/DapoxetineHCl/Dapoxetinehydrochloride;LY-210448hydrochloride;Priligy;PRILIGY;LY-210448HYDROCHLORIDE;(S)-N,N-dimethyl-3-
Dapoxetine Hydrochloride Properties
| Melting Point | 175-179°C |
| Specific Rotation | D +135.78° (c = 2.18 in methanol) |
| Storage Condition | Room Temp |
| Solubility | Dimethyl Sulfoxide: ≥20 Mg/Ml |
| Form | Powder |
| Color | color |
| Optical Activity | [α]/D +125 to +135°, c = 1 in methanol |
Dapoxetine Hydrochloride Usage and Synthesis Method
Introduction
The Chemical Name of Dapoxetine Hydrochloride Is (S)-N, N-Dimethyl-3-(Naphthyl-1-Oxy)-Phenylpropylamine Hydrochloride. Dapoxetine Hydrochloride Has Similar Pharmacological Effects to Other Ssris. Dapoxetine Was Originally Studied as an Antidepressant Drug, But Unlike Other Ssris, The Pharmacokinetics of Dapoxetine Show That It Has Rapid Oral Absorption, Short Half-Life, And Rapid Excretion, Making It a Drug Suitable for Timely Use to Treat Premature Ejaculation.
Nature
Dapoxetine Hydrochloride Is a White to Off-White Powder; It Is Easily Soluble in Methanol and Ethanol, Slightly Soluble in Dichloroethane, And Almost Insoluble in Water. Dapoxetine Hydrochloride Is a Bcs Ii Compound, And Poor Solubility Is a Key Factor Affecting Clinical Efficacy Differences. Dapoxetine Hydrochloride Has a Variety of Crystal Forms, And the Solubility of Different Crystal Forms Varies Greatly, And There Is a Phase Transformation Phenomenon Between the Crystal Forms.
Application
Dapoxetine Impurities Are Organic Synthesis Intermediates and Pharmaceutical Intermediates. They Can Be Used in Laboratory Research and Development Processes and Chemical Pharmaceutical Synthesis Processes, Mainly as an Intermediate for the Raw Material Drug Dapoxetine Hydrochloride.
In Vitro Studies
Dapoxetine Not Only Reduces the Peak Amplitude of Kv4.3 Current but Also Accelerates the Decay Rate of Current Inactivation in a Concentration-Dependent Manner. Dapoxetine Reduces the Duration of the past Polarizing Pulse of Kv4.3 Current with an Ic 50 of 5.3 μm. Dapoxetine Also Causes Accelerated Inactivation of the Bulk Closed State. Dapoxetine Produces a Significant Use-Dependent Block Accompanied by a Delayed Recovery from the Inactivation of Kv4.3 Current. Dapoxetine Reduces the Peak Amplitude of Kv1.5 Current and Accelerates the Decay Rate of Current Inactivation in a Concentration-Dependent Manner with an Ic 50 of 11.6 μm. Dapoxetine Reduces the Tail Current Amplitude and Slows down the Inactivation Process of Kv1.5, Which Leads to the Tail Permeability Phenomenon.Dapoxetine Produces a Use-Dependent Block of Kv1.5 at 1 and 2 Hz Frequencies and Slows the Time Course of Recovery from Inactivation. Dapoxetine Also Appears to Be a Useful Adjunct to Morphine, Lowering the Analgesic Threshold, Although Dapoxetine Itself Has Negligible Analgesic Activity. Dapoxetine Is the D-Enantiomer of Ly243917, Which Is 3.5 Times More Potent Than the L-Enantiomer as a Serotonin Reuptake Inhibitor.
