Capryloyl Salicylic Acid CAS 78418-01-6
capryloyl salicylic acid CAS 78418-01-6

Capryloyl Salicylic Acid CAS 78418-01-6

capryloyl salicylic acid CAS 78418-01-6, capryloyl salicylic acid, CAS 78418-01-6

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The formation of β -LHA is not accidental. It is a salicylic acid derivative carefully synthesized by ingeniously introducing lipophilic hydrocarbon groups based on the specific chemical structure of the salicylic acid benzene ring.

78418-01-6

C15H20O4

264.32

417-790-1

Capryloyl Salicylic Acid CAS 78418-01-6 Information


Chemical Name

Capryloyl Salicylic Acid

Other Name

2-Hydroxy-5-octanoylbenzoic acid; β-LHA (β-lipohydroxyacid, long-chain fatty hydrocarbon-β-hydroxycarboxylic acid)

CAS

78418-01-6

EINECS

417-790-1

Type

Cosmetic raw materials; Flavors and fragrances; Pharmaceutical, pesticide, and dye intermediates; Pharmaceutical raw materials; Organic raw materials

Molecular Formula

C15H20O4

Molecular Weight

264.32


Capryloyl Salicylic Acid CAS 78418-01-6 Properties


Melting point 

115 °C

Boiling point 

454.8±35.0 °C(Predicted)

density 

1.144

vapor pressure 

97.3Pa at 21℃

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol

pka

2.68±0.10(Predicted)

form 

powder to crystal

color 

White to Almost white

Water Solubility 

29.7mg/L at 20℃



What is Capryloyl Salicylic Acid CAS 78418-01-6?


In today's cosmetics field, there is an active compound that has attracted much attention - decyl salicylic acid, which is also commonly known internationally as β -LHA (β -lipohydroxy acid, long-chain aliphatic hydrocarbon - β -hydroxycarboxylic acid). In recent years, with the continuous advancement of cosmetic research and development technology and the increasingly in-depth exploration of skin care needs, this unique substance has gradually emerged and become the focus of attention for many cosmetic researchers.


The formation of β -LHA is not accidental. It is a salicylic acid derivative carefully synthesized by ingeniously introducing lipophilic hydrocarbon groups based on the specific chemical structure of the salicylic acid benzene ring. This subtle change in the chemical structure has brought about significant property changes, the most prominent of which is that its lipophilicity has been significantly enhanced compared to salicylic acid.


This enhancement of lipophilicity endows β -LHA with unique skincare advantages. It can not only perfectly maintain the outstanding effects of salicylic acid in exfoliating and improving aged keratin, but also further enhance the affinity with skin cells on this basis. It should be known that skin cells, as the basic components of the skin, their affinity with skin care ingredients plays a crucial role in the effectiveness of skin care. When the affinity of β -LHA with skin cells is enhanced, it seems to have a "key" to unlock the deep channels of the skin, enabling it to penetrate into the stratum corneum more easily and freely. It is precisely because of these excellent properties that β -LHA has shone brightly in the field of cosmetics. As an ideal topical ingredient, it is widely used in various skin care products, playing an important role in delaying aging and treating blackheads, bringing new hope and choices to many people who pursue beauty and health.


To gain an in-depth understanding of the actual skin care effect of β -LHA, researchers carefully designed and carried out a short-term comparative study. In this study, they made a detailed comparison between β -LHA at a concentration of 2% and the common functional ingredient additives in cosmetics. Among them, the selected comparative components were all-trans retinoic acid (RA) with a concentration of 0.05% and glycolic acid (GA) with a concentration of 10% respectively.


After a rigorous experimental process and detailed data analysis, the final research results are remarkable. Studies have found that β -LHA, like RA, has an extremely obvious repair effect on skin that undergoes degenerative changes due to photoaging. Specifically, after the use of β -LHA, the skin condition that originally had atypical epidermal hyperplasia was effectively corrected. Those abnormal keratinization phenomena gradually returned to normal. Meanwhile, the atrophied epidermal tissue also showed a positive improvement trend. Not only that, β -LHA can also significantly increase the size and quantity of clear keratin particles, causing the particle layer to gradually thicken. Under its influence, the stratum corneum gradually thins, and the epidermis as a whole also becomes thinner. This series of changes work together to gradually restore the skin to a healthier and younger state.


What is even more worth mentioning is that β -LHA can also reduce the number of melanosomes. This effect is directly reflected in the appearance of the skin, achieving the effect of whitening the skin and making the user's skin glow with a brighter and more transparent luster.



Capryloyl Salicylic Acid CAS 78418-01-6 Uses


In today's skincare field, the research and application of various effective ingredients have always been a hot topic of great concern. Among them, there is one ingredient that has demonstrated outstanding performance in exfoliation, and that is octyl salicylic acid. After a large number of experiments and practical verifications, 1.5% octyl salicylic acid has a better exfoliating effect than the commonly used 5% salicylic acid.


It should be known that the metabolism of the skin is a complex and delicate process, and the renewal of the stratum corneum is a crucial part of it. 1.5% octyl salicylic acid performs well in exfoliation because it has a unique mechanism of action. It can penetrate deep into the skin, precisely act on the relevant cells, and effectively promote cell division and proliferation. During this process, the number of cell nuclei will increase significantly. Through rigorous experimental comparison, it can be clearly found that the cell proliferation index of 1.5% capylic acid salicylic acid is significantly higher than that of 5% salicylic acid, the blank group and the excipient group.


When cells start to proliferate from the basal layer, a series of positive changes will be brought about. The basal layer, as the "foundation" of the skin, provides a more solid basis for the healthy growth of the skin as its thickness increases. The Martensitic layer, as an important component of the epidermis, the significant increase in its thickness further optimizes the structure of the skin. During this process of cell proliferation and growth from the inside out, the skin achieves renewal and growth from the bottom up. This metabolic growth of the underlying skin tissue is like injecting new vitality into the skin, greatly promoting the improvement of skin appearance. This improvement is not insignificant but can be truly felt by the dermatologists and volunteers involved in the study. In their daily observations and self-experiences, they have all noticed positive changes in their skin condition, such as the skin becoming smoother and more delicate, and the color becoming more uniform.


Not only does it perform well in exfoliation, but it also has a remarkable effect in improving acne-prone skin. To gain a deeper understanding of its practical effect in acne treatment, researchers conducted a rigorous comparative experiment. In the experiment, 0.3% octanoic acid salicylic acid preparation and 5% benzoyl peroxide were selected for comparison. After a period of observation and data collection, the results were surprising. The number of both inflammatory and non-inflammatory lesions has decreased significantly. Moreover, through statistical analysis, there is no significant difference between the two treatment methods. This result fully demonstrates the strong power of octane salicylic acid in improving acne-prone skin and also shows us its great potential in the field of skin care. Its significance lies in providing a new option for those with acne-prone skin. It can serve as an equally effective alternative to benzoyl peroxide, bringing new hope and solutions to people troubled by acne.


In addition, octyl salicylic acid also has remarkable effects in improving wrinkles and pigmentation. To explore its specific efficacy in this aspect, researchers carefully designed an experimental study. In the experiment, 5% - 10% caprylic acid salicylic acid (LHA) and 20% - 50% glycolic acid (GA) were used for comparative experiments. Through the observation of a large number of samples and data analysis, the results show that octanoic acid salicylic acid is more effective than high-concentration glycolic acid in improving wrinkles and pigmentation. This discovery undoubtedly brings new ideas and methods to the field of anti-wrinkle and spot-fading skin care, making the position of octyl salicylic acid in the skin care industry more stable.

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