Impurities in Palbociclib

English Synonyms：

2,5-Dibromopyridine;pyridine, 2,5-Dibromo-;dibromopyridine;2,5-Dibromopyridine, 97+%;2,5-Dibromopyridine;2,5-Dibromopyridine 2,5-Dibromopyridine;2,5 -Dibromopyridine,98%;2,5-Dibromopyridine, 97% 10gr

2,5-Dibromopyridine Properties

Physical and chemical properties

2,5-Dibromopyridine is a light brown crystalline solid at room temperature and pressure. It is insoluble in water and soluble in highly polar organic solvents. It is remarkably alkaline.

use

2,5-Dibromopyridine is a compound useful in organic synthesis.

application

2,5-Dibromopyridine is an organic synthesis intermediate and pharmaceutical intermediate, which can be used in laboratory research and development processes and chemical and pharmaceutical synthesis processes.

synthesis

2-Amino-5-bromopyridine (13.0kg) was added to water cooled to 10°C, and then 47% aqueous hydrogen bromide solution (37L) was added thereto. Add liquid bromine (11L) to the mixture. Keep the temperature of the reaction mixture below 10°C, add NaNO2 (16.1kg) and H2O (19L) solution dropwise to the mixture, and keep the reaction temperature at 0~5°C. The reaction mixture was continued to stir for 30 minutes. The mixture was treated with a solution of NaOH (28.0kg) in water (30L) at a rate not exceeding 20-25°C, and then the reaction mixture was extracted with diethyl ether (3×40L) to separate out the organic layer and dried it with anhydrous Na2SO4, filtered to remove the desiccant, the resulting filtrate was evaporated to dryness under reduced pressure, and finally the residue was suspended in heptane (10L), and the residue was collected by filtration to obtain 2,5-dibromo Pyridine.