4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- cas 162012-67-1-Deshangchemical

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- cas 162012-67-1

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English synonyms：4-Quinazolinamine,N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-;N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine;4 -(3-chloro-4-fiuoro-phen...;4-(3-chloro-4-fiuoro-phenylaMino)-7-fluoro-6-nitroquninazoline;N-(3-chloro-4-fluorophenyl)-N -(7-fluoro-6-nitroquinazolin-4-y

CAS

162012-67-1

Molecular Formula

C14H7ClF2N4O2

Molecular weight

336.68

EINECS

000-000-0

English synonyms：

4-Quinazolinamine,N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-;N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine;4 -(3-chloro-4-fiuoro-phen...;4-(3-chloro-4-fiuoro-phenylaMino)-7-fluoro-6-nitroquninazoline;N-(3-chloro-4-fluorophenyl)-N -(7-fluoro-6-nitroquinazolin-4-yl)acetaMide;(3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl)amine;N-(3-Chloro-4-fluorophenyl )-7-fluoro-6-nitro-4-quinazolinamine;AfatinibintermediateA

N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine Properties：

Melting Point	242-244℃
Boiling Point	489℃
Density	1.616
Flash point	249℃
Storage conditions	2-8°C(protect from light)
Solubility	Dmso (Slightly Soluble), Methanol (Slightly Soluble, Ultrasonic Treatment)
Form	Solid
Acidity coefficient (pKa)	5.07±0.70(Predicted)
Color	Yellow to Deep Yellow

Usage:

N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitro-4-Quinazolinamine Is an Intermediate in the Synthesis of Afatinib, Which Is an Aminocroton Amido-Substituted Quinazoline Derivatives Used in the Treatment of Cancers and Diseases of the Respiratory Tract and Lungs, Gastrointestinal Tract, Bile Ducts and Gallbladder.

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