English Synonyms
(S)-TETRAHYDROFURAN-3-OL;(S)-(+)-TETRAHYDRO-3-FURANOL;(S)-(+)-3-HYDROXYTETAHYDROFURAN;(S)-(-)-3-HYDROXYTETRAHYDROFURAN;(3S)-oxolan-3-ol;(2S)-1,4-Epoxy-2-hydroxybutane,(3S)-Tetrahydrofuran-3-ol,(3S)-Oxolan-3-ol;AfatinibintermediateB;(S)-(+)-3-Hydroxytetrahydrofuran,ee:95%
(S)-(+)-3-Hydroxytetrahydrofuran Properties
| Specific Rotation | 18.5 º (c=2 MeOH) |
| Boiling Point | 80 °C/15 mmHg (lit.) |
| Density | 1.103 g/mL at 25 °C (lit.) |
| Vapor Pressure | 47Pa at 25℃ |
| Refractive Index | n20/D 1.45(lit.) |
| Flash Point | 175 °F |
| Storage Condition | Keep in Dark Place,Sealed in Dry,Room Temperature |
| Form | Liquid |
| Acidity Coefficient (pKa) | 14.49±0.20(Predicted) |
| Color | Transparent Colorless to Light Yellow |
| Stability | Stable. Flammable. Incompatible with Strong Oxidizing Agents. |
(S)-(+)-3-Hydroxytetrahydrofuran Usage and Synthesis
Introduction
S)-(+)-3-Hydroxytetrahydrofuran Is a Colorless to Light Yellow Transparent Liquid and Can Be Used as a Chemiluminescence Analysis Detection Reagent.
Use
The Synthesis of the Anti-Aids Drug Amprenavir Requires Two Important Intermediates, One of Which Is (S)-(+)-3-Hydroxytetrahydrofuran. It Can Be Synthesized by Asymmetric Hydroboration or Hydrosilylation of Dihydrofuran, Asymmetric Hydrogenation Reduction-Intramolecular Etherification of 4-Chloro-3-Carbonylbutyrate, And Enzymatic Resolution of 3-Hydroxytetrahydrofuran Racemate, But in Most Cases the Optical Purity of the Product Is Insufficient.
