Afatinib Impurities

English synonyms：

2-Chloro-1-Fluoro-4-Nitro-Benzen;benzene,2-Chloro-1-Fluoro-4-Nitro-;benzene,2-Chloro-1-Fluoro-4-Nitro-;2-Chloro-1- Fluoro-4-Nitchemicalbookrobenzene;1-Chloro-2-Fluoro-5-Nitrobenzene;3-Chloro-4-Fluoronitrobenzene;4-Fluoro-3-Chloronitrobenzene;3-Chloro-4-Fluorobenzene

Introduction: 

2-Chloro-1-Fluoro-4-Nitrobenzene, Also Called 3-Chloro-4-Fluoronitrobenzene, Is an Intermediate of Norfloxacin and Can Also Be Used to Prepare 3-Chloro-4-Fluoroaniline. The Basic Raw Materials for the Synthesis of Drugs Such as Quinolic Acid Can Also Be Used in Pesticide Production and Other Aspects. 3-Chloro-4-Fluoronitrobenzene Can Be Used to Prepare 3-Chloro-4-Fluoroaniline Hydrochloride, Which Is a Very Important Starting Point in the Synthesis of the Anticancer Drug Gefitinib. It Is a Raw Material and an Important Intermediate for the Synthesis of the Antibacterial Drug Norfloxacin. In Addition, 3-Chloro-4-Fluoroaniline Is Also an Important Intermediate for the Synthesis of Fluorine-Containing Pesticides, Herbicides, Plant Growth Regulators, Fungicides, Etc.

Application: 

3-chloro-4-fluoronitrobenzene is an important pharmaceutical and pesticide intermediate. If 3-chloro-4-fluoroaniline is obtained by reduction, norfloxacin can be obtained. If chlorination and denitrification are used, 2,4 -Dichlorofluorobenzene, which can be obtained from ciprofloxacin through further synthesis.

Chemical Properties:

 White crystal. The melting point is 44-47℃, the boiling point is 227-237℃, and the flash point is >110℃.

Usage:

 Intermediate of norfloxacin. It can also be used to prepare 3-chloro-4-fluoroaniline, which is the basic raw material for the synthesis of quinolic acid and other drugs.

Usage: 

It is an important pharmaceutical and pesticide intermediate. If 3-chloro-4-fluoroaniline is obtained by reduction, norfloxacin can be obtained. If 2,4-dichlorofluorobenzene is obtained by chlorination and denitrification, it can be prepared by further synthesis. Get ciprofloxacin.

Production method: 

Nitrate fluorobenzene with mixed acid to generate p-fluoronitrobenzene, and then chlorine it with chlorine gas to prepare this product.