English Synonyms
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone;Methanone,(2-chloro-5-iodophenyl)(4-fluorophenyl)-;(2-Chloro-5-iodobenyl)(4-fluorophenyl)methanone;EmpagliflozinImpurity48;EnglenetImpurity16;2-chloro-4-fluoro-5-Iodobenzophenon;(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanon;2-Chloro-4'-fluoro-5-iodobenzophenone
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Properties
| Melting Point | 64-70℃ |
| Boiling Point | 415℃ |
| Density | 1.752 |
| Flash Point | 205℃ |
| Storage Condition | Under Inert Gas (Nitrogen or Argon) at 2–8 °c |
| Solubility | Soluble in Chloroform (A Small Amount), Ethyl Acetate |
| Form | Solid |
| Color | Off White |
Usage and Synthesis of (2-Chloro-5-iodophenyl)(4-fluorophenyl)ketone
Overview
(2-Chloro-5-Iodophenyl)(4-Fluorophenyl)methanone Is an Intermediate in the Synthesis of Empagliflozin. Empagliflozin Is a Sodium-Glucose Co-Transporter Type 2 Inhibitor Developed Jointly by Boehringer Ingelheim and Eli Lilly. Sglt-2 Inhibitors Are a New Type of Hypoglycemic Drug That Mainly Inhibits Sglt-2 Expressed in the Kidneys, Reduces Glucose Reabsorption by the Kidneys, And Increases Glucose Excretion in the Urine, Thereby Reducing Plasma Glucose Levels. Its Hypoglycemic Effect Is Independent of β-Cell Function and Insulin Resistance.
