English Synonyms
(R)-Bis-3,5-Trifluoromethyl-1-Phenylethanol;rolapitantintermediate3;(R)-1-[3,5-Bis(Trifluoromethyl)phenyl]ethanol127852-28-2;(R)-1-[3,5-Bis(Trifluoromethyl)phenyl]ethanol,99%e.E.;fosaprepitantimpurity25;aprepitantimpurity49;(R)-1-[3,5-Bis(Trifluoromethyl)phenyl]ethanol（aprepitant）;(R)-1-[3,5-Bis(Trifluoro-Methyl)-Phenyl]ethanol98%
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Chemical Properties
| Melting point | 53-58℃ |
| Boiling Point | 175.8±35.0 °C(Predicted) |
| Density | 1.376±0.06 g/cm3(Predicted) |
| Storage conditions | -20°C Freezer |
| Solubility | Soluble in acetonitrile (a little), chloroform (a little) |
| Acidity coefficient (pKa) | 13.99±0.20(Predicted) |
| Form | powder |
| Color | White |
| Optical activity | [α]/D +27±1°, c = 1 in acetonitrile |
| Maximum wavelength (λmax) | 272nm(MeOH)(lit.) |
Overview
R)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol is an important chiral intermediate for the synthesis of the antiemetic drug Aprepitant
Uses
(R)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol is mainly used to treat depression and chemotherapy-induced vomiting; can prevent acute and delayed nausea and vomiting caused by the first and subsequent repeated chemotherapy; API aprepitant/aprepitant intermediate; aprepitant morpholine hydrochloride side chain.
Preparation
Dissolve 3,5-bis(trifluoromethyl)acetophenone in methanol, add 2% sodium borohydride in sodium hydroxide solution dropwise under ice bath, react for 2 hours, adjust with hydrochloric acid until no bubbles emerge, distill to remove methanol solvent, cool, extract with dichloromethane, dry and concentrate to obtain racemic product.
Uses
Aprepitant side chain
![(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol cas 127852-28-2](/static/upload/image/20240530/1717059137420186.jpg)